In Sanctum 2 players assume the role of one of four elite soldiers, each with their own unique abilities and weapons whose mission is to protect the Cores from hordes of mysterious alien creatures on the human colony planet, LOEK III. Melding the best elements of the tower defense and first-person genres, players are challenged to protect the Cores.

In each scenario, players must set up defensive towers to take out waves of attacking enemies and ensure victory. However, Sanctum 2 is not just a game where players sit back and watch the action unfold. Instead they jump into the fray head-on in FPS mode to light up the opposition with a wide array of weapons, some of which you’ve never seen before in an FPS game.